Sorbus aucuparia L. Fruit Is a Source of the Drug for Increasing
the Efficiency of Tumor Chemotherapy
N. V. Isaikinaa, 1, G. I. Kalinkinaa, T. G. Razinab, E. P. Zuevab, O. Yu. Rybalkinab, c,
A. V. Ulirichb, E. P. Fedorovab, and A. B. Shilovaa
Translated by E. Makeeva
aSiberian State Medical University, Tomsk, 634050 Russia
bTomsk National Research Medical Center, Russian Academy of Sciences, E.D. Goldberg Scientific Research
Institute of Pharmacology and Regenerative Medicine, Tomsk, 634028 Russia
cNational Research Tomsk State University, Tomsk, 634050 Russia
1The corresponding author; е-mail: nadezhda.isaykina@ gmail.com.
Received 21 February, 2017
Abstract—The composition of phenolic compounds of rowanberry (Sorbus aucuparia L.) fruit extracts prepared with 40% ethanol and 95% acidified ethanol was studied. The differences in the content of flavonoids, including anthocyanins, and phenolic acids were shown. It was found that the antimetastatic activity of cyclophosphamide was most efficiently increased by the rowanberry fruit extract in 95% acidified ethanol enriched in anthocyanins. The aim of the present research was to investigate the effect of hydroalcoholic extracts of rowanberry fruit on the development of Lewis lung carcinoma and the antitumor activity of cyclophosphamide and to reveal the most effective extract containing a phenolic complex for its further study as a promising drug.
Keywords: rowanberry fruit extracts, phenolic compounds, Lewis lung carcinoma, anthocyanins, antimetastatic activity
DOI: 10.1134/S1068162018070038